Medchemexpress LLC Abemaciclib (methanesulfonate) | 1231930-82-7 | 99.8% | 602.70 | 200 MG

Supplier:  Medchemexpress LLC HY16297200MG

This compound is a selective and BBB-permeable inhibitor of CDK4/6, with half-maximal inhibitory concentrations (IC50s) of 2 nM and 10 nM for CDK4 and CDK6, respectively.

• Selective inhibition of key enzymes involved in cell cycle regulation.
• Permeates the blood-brain barrier.
• Reduces cell viability in various human cell lines, including HCT-116, MCF7, and PANC-1.
• Inhibits Rb phosphorylation, leading to a G1 arrest and suppressed proliferation.
• Activity is specific for cells that are proficient in Rb.
• Effective in reducing cell viability across multiple cancer cell lines.
• Demonstrates antiproliferative activity against human HCT116 and MCF7 cells.
• Shows inhibition in resistant cell lines.
• Causes a cooperative antitumor effect when combined with other agents in xenograft models.
• Leads to significant tumor growth inhibition in xenograft models.

Catalog No. 50-003-92812