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ABclonal Technology ABflo 488 Rabbit anti-Dog CD19
Supplier: ABclonal Technology A27217200T
This gene encodes a cell surface protein from the immunoglobulin gene superfamily expressed mainly in B cell lymphocytes It serves as a marker for pre-B cells but is downregulated in antibody-secreting plasma cells The protein features two extracellular Ig-like domains a non-Ig-like domain a hydrophobic transmembrane region and a large C-terminal cytoplasmic domain It forms a complex with CD21 and CD81 reducing the activation threshold for B cells Activation of this complex triggers the phosphatidylinositol 3-kinase pathway and calcium ion release This protein is targeted by CAR T-cells in lymphoblastic leukemia treatment Mutations are linked to common variable immunodeficiency 3 (CVID3) causing B-cell differentiation failure hypogammaglobulinemia and recurrent infections Alternative splicing produces multiple isoforms
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