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Eurofins Discoverx Abl (Q252H), active, 10 µg. (14-751)
Supplier: Eurofins Discoverx 14751
N-terminal 6xHis-tagged recombinant, human Abl, amino acids 27-end containing the Q252H mutation. The Abl tyrosine kinase inhibitor STI571 is an effective therapy for stable-phase chronic myeloid leukemia patients. Many patients responding to STI571 later relapse due to a reactivation of Bcr-Abl activity. In certain cases this appears to correlate with the presence of the Q252H mutation, which confers resistance to drug binding (Shah et al., (2002), Cancer Cell 2, 117-125). For detailed product information, visit www.discoverx.com/proteins.
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