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Apexbio Technology LLC ABT-199 1257044-40-8 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A81945.1

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ABT-199 (CAS 1257044-40-8) is a selective small-molecule inhibitor targeting BCL-2 developed through structure-guided drug design By specifically interfering with the mitochondrial apoptotic pathway regulated by BCL-2 ABT-199 induces apoptosis predominately in cells dependent on BCL-2 signaling rather than BCL-XL In preclinical assessments ABT-199 exhibited antitumor activity against hematologic malignancies including BCL-2-dependent non-Hodgkin lymphoma (NHL) and acute myeloid leukemia (AML) cell lines and xenograft models while demonstrating minimal platelet toxicity

Catalog No. 50-000-61688


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