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Medchemexpress LLC ABT-639 | 1235560-28-7 | 99.3% | 455.91 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1972150MG

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ABT-639 is a novel, peripherally acting, selective T-type Ca2+ channel blocker. It is used for research purposes only and not sold to patients. It effectively reduces nociceptive and neuropathic pain in rats.

  • Blocks recombinant human T-type (Cav3.2) Ca2+ channels in a voltage-dependent fashion.
  • Attenuates low voltage-activated (LVA) currents in rat DRG neurons.
  • Significantly less active at other Ca2+ channels (e.g., Cav1.2 and Cav2.2).
  • High oral bioavailability (%f=73) in rodents.
  • Low protein binding (88.9%) in rodents.
  • Low brain:plasma ratio (0.05:1) in rodents.
  • Produces dose-dependent antinociception in a rat model of knee joint pain.
  • Increases tactile allodynia thresholds in multiple models of neuropathic pain.
  • Does not significantly alter hemodynamic or psychomotor function at higher doses.

Catalog No. 50-004-01701


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