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Medchemexpress LLC ABT-737-d8 | 1217686-68-4 | 99.1% | C42H37D8ClN6O5S2 | 1 MG
Supplier: Medchemexpress LLC HY50907S1MG
ABT-737-d8 is a deuterium labeled ABT-737, a potent BH3 mimetic that inhibits Bcl-2, Bcl-xL, and Bcl-w. It induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 also induces autophagy and has potential for acute myeloid leukemia (AML) research. Deuteration can affect pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer for quantitative analysis
- Can be an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
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