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Medchemexpress LLC Abt-737-d8 | 1217686-68-4 | 99.1% | C42H37D8ClN6O5S2 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY50907S5MG

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ABT-737-d8 is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. It induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 also induces autophagy and has the potential for acute myeloid leukemia (AML) research.

  • Can be used as a tracer.
  • Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
  • Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

Catalog No. 50-003-58288


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