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Enzo Life Sciences ABT-888 (5mg). CAS: 912445-05-7
Supplier: Enzo Life Sciences ALX270444M005
Potent inhibitor of PARP-1 and PARP-2 (potency ≤5nM in vitro). Does not inhibit other NAD-binding enzymes. Has minimal CYP450 inhibition and induction. Shows broad spectrum of chemo- and radiopotentiation. Is toxic to both oxic and hypoxic cells. Enantiomeric purity ≥97% suitable for in vivo studies. Does not show inherent cytotoxicity and shows no single agent activity in tumor models. Has excellent bioavailability and good blood-brain permeation. Increases tumor growth delay resulting from radiation and DNA-damaging agents. Alternative name: 2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide . dihydrochloride. Purity: ≥98% (HPLC). Appearance: Colorless to white crystalline solid. Solubility: Soluble in water or DMSO. Long Term Storage: -20°C.
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