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Apexbio Technology LLC ABT-888 (Veliparib) 912444-00-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A30025.1
ABT-888 (Veliparib CAS 912444-00-9) is a potent inhibitor of poly (ADP-ribose) polymerase (PARP) a key enzyme involved in DNA damage repair processes Elevated levels of PARP are associated with resistance to cytotoxic chemotherapy and radiotherapy Preclinical studies demonstrate that combining Veliparib with various cytotoxic agents enhances antitumor activity in vivo Additionally ABT-888 exhibits activity in microsatellite instability (MSI) cancer cell lines harboring mutations in DNA repair genes such as MRE11 and RAD50 Thus Veliparib is frequently employed in research exploring chemotherapeutic sensitization strategies
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