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Medchemexpress LLC AC-186 | 1421854-16-1 | 99.6% | 306.32 | 1 MG
SDP

Catalog No. 5000345012
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AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. It has shown gender-selective neuroprotective effects in a male rat model of Parkinson's disease.

  • Selective non-steroidal estrogen receptor β (ERβ) agonist.
  • EC50s of 6 nM for ERβ and 5000 nM for ERα.
  • Shows gender-selective neuroprotective effects in a male rat model of Parkinson's disease.
  • Inhibits growth of LNCaP cells at 10 μM (72 h) and has no effect on PC3 cells.
  • In vivo, 10 mg/kg (s.c.; once) prevented motor, cognitive, and sensorimotor gating deficits and mitigated the loss of dopamine neurons in the substantia nigra, in males, but not in females, in a male rat model of Parkinson's disease.

Catalog No. 50-003-45012 Supplier Medchemexpress LLC Supplier No. HY11015750MG
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AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. It has shown gender-selective neuroprotective effects in a male rat model of Parkinson's disease.

  • Selective non-steroidal estrogen receptor β (ERβ) agonist.
  • EC50s of 6 nM for ERβ and 5000 nM for ERα.
  • Shows gender-selective neuroprotective effects in a male rat model of Parkinson's disease.
  • Inhibits growth of LNCaP cells at 10 μM (72 h) and has no effect on PC3 cells.
  • In vivo, 10 mg/kg (s.c.; once) prevented motor, cognitive, and sensorimotor gating deficits and mitigated the loss of dopamine neurons in the substantia nigra, in males, but not in females, in a male rat model of Parkinson's disease.

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