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Apexbio Technology LLC AC 45594 13037-86-0 50mg
Supplier: Apexbio Technology LLC B725250
AC 45594 (CAS 13037-86-0) is a synthetic inverse agonist of steroidogenic factor-1 (SF-1) a constitutively active nuclear receptor regulating adrenal/gonadal differentiation and steroid hormone biosynthesis By binding SF-1 it inhibits SF-1 mediated transcription and modulates steroidogenic gene expression In human adrenal cortical H295R cells AC 45594 suppresses SF-1 transcriptional activity with an IC of 50 100 nM reduces cyclic AMP induced StAR mRNA and protein expression and dose-dependently decreases proliferation while promoting apoptosis in SF-1 overexpressing cells These properties support its research use in studying SF-1 dependent regulation of steroidogenesis proliferation and survival in adrenal and endocrine models
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