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Medchemexpress LLC Ac-Cys-Pro-Pro-Tyr-Leu-Pro-cyclo(Lys-Tyr-Leu-Cys-Asp)-Leu-Ile-NH2 (disulfide bridge :Cys1-Cys10) | 99.0% | 1672.93 | 10 MG
SDP

Supplier:  Medchemexpress LLC HYP6292A10MG

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KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2), primarily used in research for schizophrenia and cancer immune regulation.

  • Highly selective and potent VIPR2 antagonist.
  • Reverses tumor-promoting M2 macrophage phenotype to anti-tumor M1, altering tumor immune microenvironment.
  • Inhibits tumor growth.
  • Can be formulated as nanoparticles to cross the blood-brain barrier.
  • Enhances anti-tumor and neuroprotective activities.
  • Prevents VIPR2 over-activation, safeguarding against cognitive impairments and neuronal structural damage in mice.
  • Demonstrates anti-tumor activity in murine models, synergistic with anti-PD-1 antibodies.

Catalog No. 50-003-97861


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