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Apexbio Technology LLC Ac-IETD-pNA 219138-21-3 25mg
Supplier: Apexbio Technology LLC A875025
Ac-IETD-pNA (CAS 219138-21-3) is a synthetic peptide substrate designed for colorimetric detection of caspase-8 activity as well as related cysteine proteases such as caspase-6 caspase-10 and granzyme B The IETD sequence within Ac-IETD-pNA corresponds to the canonical cleavage site recognized by caspase-8 enabling specific substrate hydrolysis during apoptosis Upon enzymatic cleavage p-nitroaniline (pNA) is released and quantified spectrophotometrically at 405 nm providing a direct measure of protease activity in cell lysates This compound is widely employed for the identification and quantification of caspase-8 activation and facilitates the study of downstream apoptotic signaling pathways in biomedical research
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