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CPC Scientific Ac-Trp-Glu-His-Asp-CHO (trifluoroacetate salt) 1MG
Supplier: CPC Scientific CASP004A
Very potent reversible inhibitor of caspase-1 (ICE) that contains the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM, it displays the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported.SEQUENCE: Ac-Trp-Glu-His-Asp-CHO (trifluoroacetate salt)ONE-LETTER SEQUENCE: Ac-WEHD-CHOMOLECULAR FORMULA: C28H33N7O9MOLECULAR WEIGHT: 611.61STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [189275-71-6]SYNONYMS: Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)RESEARCH AREA: ApoptosisREFERENCES:T.A. Rano, T. Timkey, E.P. Peterson, J. Rotonda, D.W. Nicholson, J.W. Becker, K.T. Chapman, and N.A. Thornberry, Chem. Biol., 4, 149 (1997).M. Garcia-Calvo, E.P. Peterson, B. Leiting, R. Ruel, D.W. Nicholson, and N.A. Thornberry, J. Biol. Chem., 273, 32608 (1998).SKU(s): CASP-004A
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