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Selleck Chemical LLC Acalabrutinib
Supplier: Selleck Chemical LLC S8116100MG
Acalabrutinib (ACP-196) is a selective second-generation Bruton s tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway ACP-196 has improved target specificity with 323- 94- 19- and 9-fold selectivity over the other TEC kinase family members (ITK TXK BMX and TEC respectively) and no activity against EGFR
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