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Selleck Chemical LLC Acalabrutinib (ACP-196) 5mg 1420477-60-6
Supplier: Selleck Chemical LLC S81165MG
Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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