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Apexbio Technology LLC Acamprosate calcium 77337-73-6 50mg
Supplier: Apexbio Technology LLC A314250
Acamprosate calcium (CAS 77337-73-6) is a synthetic small molecule widely investigated for its role in reducing ethanol intake particularly in models of alcohol dependence Structurally analogous to GABA acamprosate selectively interacts with GABAB receptors while also exhibiting serotonergic properties by enhancing 5-HT levels and related responses following ethanol exposure In vivo studies demonstrate that oral administration of acamprosate at doses ranging from 50 to 400 mg/kg/day can dose-dependently suppress voluntary ethanol consumption in rodents Additionally acamprosate modulates excitatory amino acid activity and diminishes Ca2 influx These attributes support its utility in preclinical research on neurochemical mechanisms underpinning alcohol use disorders
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