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Medchemexpress LLC ACBI1 | 2375564-55-7 | 99.9% | 50 MG
Supplier: Medchemexpress LLC HY12835950MG
ACBI1 is a potent and cooperative degrader of SMARCA2, SMARCA4, and PBRM1, functioning as a PROTAC degrader that demonstrates anti-proliferative activity and induces apoptosis. It has DC50s of 6, 11, and 32 nM for SMARCA2, SMARCA4, and PBRM1, respectively.
- Targets VHL, SMARCA2, SMARCA4, and PBRM1
- Exhibits antiproliferative activity against human MV4-11 cells (IC50 of 28 nM)
- Induces apoptosis in SK-MEL-5 cells
- Soluble in DMSO at ≥ 100 mg/mL (106.83 mM)
- Formulations available for in vivo use with 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline or 10% DMSO, 90% Corn Oil
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