AdipoGen ACBP h rec His

Supplier:  AdipoGen AG40B0197C050

Recombinant protein. Human acyl-CoA-binding protein aa 2-87 is fused at the C-terminus to a His-tag. Endotoxin <0.01EU/µg purified protein LAL test. Lyophilized. Contains PBS. Acyl-coenzyme A CoA-binding protein ACBP is an ubiquitously expressed 86 aa polypeptide that binds medium- and long-chain acyl-CoA esters with very high affinity. It plays a role as an intracellular carrier of acyl-CoA esters and regulates lipid metabolism in the cytoplasm of most cell types. In addition to its function within the cells as acyl-coenzyme A CoA-binding protein, ACBP also functions as secreted protein called Diazepam-Binding Inhibitor DBI that can interact with the benzodiazepine-binding site of the gamma-aminobutyric acid GABA type A receptor, GABAAR, and modulate its activity. ACBP is secreted upon induction of autophagy energy deficiency in different organisms including mouse and human. ACBP levels correlate with human body mass index BMI.

Catalog No. 50-256-2891