Medchemexpress LLC Acesulfame potassium | 55589-62-3 | 99.38% | 5 G

Supplier:  Medchemexpress LLC HYD01955G

Acesulfame potassium is a synthetic sweetener that can affect cognitive function and may be related to immune evasion in cancer cells by suppressing autophagic degradation of PD-L1. It is for research use only and suitable for studies on neurological diseases, metabolic disorders, cancer, and immune evasion.

• Upregulates PD-L1 protein levels in RIL-175 and SK-Hep1 cells.
• Increases granzyme B production in RIL-175 and SK-Hep1 cells co-cultured with T cells.
• Activates ERK1/2-mTORC1-ULK1 pathway to suppress autophagic degradation of PD-L1.
• Inhibits mitochondrial metabolism and ATP production in SH-SY5Y cells.
• Impairs energy metabolism and neuroprotective functions.
• Increases body weight in male CD-1 mice and alters gut microbiome.
• Affects neurometabolic functions in C57BL/6J mice with long-term intake.

Catalog No. 50-004-10976