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Medchemexpress LLC Acetamide, 2-[[7-(3,4-dimethoxyphenyl)-2-quinoxalinyl]amino]-N-methyl- | 1513879-21-4 | 99.9% | 352.39 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY18748100MG

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BQR-695 is a PI4KIIIβ inhibitor with IC50s of 80 nM for human PI4KIIIβ and 3.5 nM for the Plasmodium variant of PI4KIIIβ. Treatment with 0.5 μM causes GFP-PHOsh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function. This inhibitor shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest, and exhibits cross-resistance with imidazopyrazine-resistant lines.

  • Potent PI4KIIIβ inhibitor
  • Effective against human and Plasmodium PI4KIIIβ variants
  • Induces schizont-stage arrest
  • No toxicity against mature red blood cells

Catalog No. 50-003-86064


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