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Medchemexpress LLC Acetamide, 2-[[7-(3,4-dimethoxyphenyl)-2-quinoxalinyl)amino]-N-methyl- | 1513879-21-4 | 99.9% | 352.39 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY187485MG

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BQR-695 is a PI4KIIIβ inhibitor, active against both human and *Plasmodium* variants of PI4KIIIβ. It effectively inhibits PI4KIIIβ function, leading to depletion of intracellular PI4P, and shows no toxicity against mature red blood cells. It induces schizont-stage arrest and exhibits cross-resistance with imidazopyrazine-resistant lines.

  • Inhibits human PI4KIIIβ with an IC50 of 80 nM
  • Inhibits *Plasmodium* PI4KIIIβ with an IC50 of 3.5 nM
  • Causes GFP-PHOsh2 to redistribute to parasite plasma membrane
  • No toxicity against mature red blood cells
  • Induces schizont-stage arrest
  • Exhibits cross-resistance with imidazopyrazine-resistant lines

Catalog No. 50-003-87916


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