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Medchemexpress LLC Acetamide, N-cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- | 1391737-01-1 | 99.8% | 382.50 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY11011010MG

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VU0463271 is a selective KCC2 antagonist, with an IC50 of 61 nM. It targets and inhibits the neuronal-specific potassium-chloride cotransporter 2 (KCC2) with over 100-fold selectivity against NKCC1. The compound shows no activity in a broader panel of GPCRs, ion channels, and transporters.

  • Selective KCC2 antagonist.
  • Exhibits an IC50 of 61 nM for KCC2.
  • Displays high selectivity (>100-fold over NKCC1) and no activity across a wide range of other GPCRs, ion channels, and transporters.
  • Shows antagonist activity at KCC2 in human HEK293 cells.
  • Significantly increases firing rates in Drosophila CNS preparations.
  • Rapidly cleared in vitro.

Catalog No. 50-003-44123


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