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Apexbio Technology LLC Acetazolamide 59-66-5 1g
Supplier: Apexbio Technology LLC B61251000
Acetazolamide (CAS 59-66-5) is a small-molecule inhibitor targeting carbonic anhydrase (CA) It is designed to inhibit CA activity thereby modulating neuronal ion flux and influencing neurotransmission Acetazolamide exerts its biological activity primarily through inhibition of carbonic anhydrase an enzyme catalyzing the reversible hydration of carbon dioxide In experimental studies acetazolamide demonstrates potent inhibition with reported IC50 values for various CA isoforms typically ranging from 5 to 30 nM depending on isoenzyme subtype and assay conditions Based on these pharmacological properties acetazolamide holds research potential in studies of neuronal excitability synaptic transmission and seizure pathophysiology including models of absence tonic-clonic myoclonic and atonic seizures
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