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Medchemexpress LLC Acetazolamide (sodium) | 1424-27-7 | 99.5% | 500 MG
Supplier: Medchemexpress LLC HYB0782A500MG
Acetazolamide sodium is a carbonic anhydrase (CA) IX inhibitor with an IC50 of 30 nM for hCA IX. It also inhibits hCA II with an IC50 of 130 nM. This small heteroaromatic sulfonamide binds to various carbonic anhydrases with high affinity, acting as a carbonic anhydrase (CA) inhibitor. It exhibits diuretic, antihypertensive, and anti-gonococcal activities.
- Reduces viability of Hep-2 cells, especially when combined with cisplatin.
- Increases P53 protein expression and caspase-3 protein expression in Hep-2 cells with combination treatment.
- Promotes apoptosis in Hep-2 cells and decreases AQP1 mRNA expression with combination treatment.
- Enhances inhibitory effect on tumorigenesis in neuroblastoma SH-SY5Y xenografts.
- Reduces expression of HIF1-α and CAIX, and mitotic and proliferative markers, in neuroblastoma SH-SY5Y xenografts.
- Significantly reduces gonococcal load in the vagina of infected mice.
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