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Cayman Chemical Acetylated Carbohydrate Mixtu
SDP

Supplier:  Cayman Chemical 293681 ML

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An mTOR inhibitor (IC50 0 009 UM) selectively inhibits mTOR over PI3Ka and PI3K (IC50s 1 96 and 8 45 UM respectively) and 24 additional lipid and protein kinases in a panel (IC50s 50 UM for all) decreases phosphorylation of Akt and S6K1 in a cell-free assay at 0 2 1 and 5 UM decreases proliferation of nine cancer cell lines including breast prostate glioma kidney and colorectal cancer cells (IC50s 0 6-2 5 UM) reduces tumor growth in a HepG2 mouse xenograft model at 10 mg/kg for 14 days

Catalog No. 50-298-8128


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