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Cayman Chemical Acetylshikonin, Purity: ≥98%, CAS: 24502-78-1, 10 mg
SDP

Catalog No. 502943461
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A naphthoquinone that has diverse biological activities; inhibits a panel of 10 CYPs (IC50s = 1.4-4.0 µM); cytotoxic to H1975, A549, PC-9, and H460 NSCLC cells (IC50s = 3.9, 4.7, 20.7, and 17.3 µM, respectively); inhibits the migration of, as well as reduces EGFR and STAT3 signaling and induces apoptosis in, H1975, PC-9, and H460 cells at 0.5, 1, and 2 µM; reduces tumor weight and intratumoral STAT3 phosphorylation in an H1975 mouse xenograft model at 1 mg/kg; inhibits SARS-CoV-2 PLpro (IC50 = 5.05 µM); reduces BALF levels of Tnf-α, Il-1α, and Il-6 in a mouse model of acute lung injury induced by poly (I:C) and SARS-CoV-2 spike glycoprotein at 300 mg/kg

Catalog No. 50-294-3461 Supplier Cayman Chemical Supplier No. 4014410 MG
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A naphthoquinone that has diverse biological activities; inhibits a panel of 10 CYPs (IC50s = 1.4-4.0 µM); cytotoxic to H1975, A549, PC-9, and H460 NSCLC cells (IC50s = 3.9, 4.7, 20.7, and 17.3 µM, respectively); inhibits the migration of, as well as reduces EGFR and STAT3 signaling and induces apoptosis in, H1975, PC-9, and H460 cells at 0.5, 1, and 2 µM; reduces tumor weight and intratumoral STAT3 phosphorylation in an H1975 mouse xenograft model at 1 mg/kg; inhibits SARS-CoV-2 PLpro (IC50 = 5.05 µM); reduces BALF levels of Tnf-α, Il-1α, and Il-6 in a mouse model of acute lung injury induced by poly (I:C) and SARS-CoV-2 spike glycoprotein at 300 mg/kg

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