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Cayman Chemical AconItase IsocItrIc Dehydroge
Supplier: Cayman Chemical 7055101 EA
A Bax activator (Ki 43.3 nM in a fluorescence polarization assay) selectively reduces viability in wild-type but not Bax-/- MEFs at 25 UM inhibits nicotine-induced increases in phosphorylated Bax levels in A549 cells at 5 UM reduces viability in A549 cells at 5 UM induces cell cycle arrest at the G2/M phase in U87MG cells at 5 10 or 15 UM disrupts the mitochondrial membrane potential in U87MG cells at 15 UM induces cytochrome c release from mitochondria and Bax insertion into mitochondrial membranes in A549 cells at 5 or 10 UM decreases tumor volume in an A549 mouse xenograft model at 40 or 60 mg/kg per day
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