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Cayman Chemical AconItase Substrate SolutIon
Supplier: Cayman Chemical 7055061 EA
An ALK5 and ALK4 inhibitor (IC50s 47 and 129 nM respectively) selective for ALK5 and ALK4 over a panel of 27 kinases at 10 UM inhibits ALK7-induced increases in phosphorylated SMAD2 levels in COS-1 cells overexpressing ALK7 at 5 UM inhibits TGF-B-induced but not TNF-a-induced apoptosis in Fao cells at 1 UM decreases IOP and subconjunctival immune cell infiltration in a rabbit model of trabeculectomy at 5 mg/eye
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