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Cayman Chemical aContoxIn ImItrIfluoroace 10mg
Supplier: Cayman Chemical 3402210 MG
A conotoxin and an antagonist of α7 nAChRs (IC50 = 220 nM); selective for α7 nAChRs over α2β2, α3β2, α4β2, α2β4, α3β4, α4β4, and α1β1γδ subunit-containing nAChRs at 5 µM but does inhibit homomeric α9 nAChRs (IC50 = 1,800 nM); administration of paclitaxel in micelles containing α-conotoxin ImI decreases tumor growth in an MCF-7 mouse xenograft model; intracerebroventricular administration of α-conotoxin ImI induces seizures in rats at 20 nmol/animal
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