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Medchemexpress LLC Acoramidis hydrochloride | 2242751-53-5 | 98.7% | 328.77 | 50 MG
Supplier: Medchemexpress LLC HY109165A50MG
Acoramidis (AG10) hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). It is utilized in the study of transthyretin amyloidosis. This compound demonstrates equal efficacy in stabilizing V122I- and WT-TTR and surpasses tafamidis in stabilizing both WT and mutant TTR in whole serum. Additionally, it exhibits minimal inhibition of common drug discovery off-targets like the hERG potassium ion channel and cytochrome P450 isozymes, indicating low toxicity.
- Stabilizes WT and V122I-TTR.
- Used in the study for transthyretin amyloidosis.
- Shows minimal inhibition of hERG and cytochrome P450 isozymes, suggesting low toxicity.
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