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Cayman Chemical Acoramidis (hydrochloride), Purity: ≥98%, CAS: 2242751-53-5, 10 mg
SDP

Catalog No. 502944414
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A TTR kinetic stabilizer; selectively binds to wild-type TTR and TTRV122I with negative cooperativity (Kd1s = 4.8 and 6.2 nM, respectively; Kd2s = 314 and 139 nM, respectively) over COX-1, COX-2, and the thyroid hormone nuclear receptor (IC50s = >10 µM for all); inhibits pH-induced amyloidogenesis of wild-type TTR and TTRV122I, indicating tetramer stabilization; stabilizes TTRV122I in serum isolated from patients with familial amyloid cardiomyopathy at 10 µM

Catalog No. 50-294-4414 Supplier Cayman Chemical Supplier No. 4153610 MG
May include imposed supplier surcharges.
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A TTR kinetic stabilizer; selectively binds to wild-type TTR and TTRV122I with negative cooperativity (Kd1s = 4.8 and 6.2 nM, respectively; Kd2s = 314 and 139 nM, respectively) over COX-1, COX-2, and the thyroid hormone nuclear receptor (IC50s = >10 µM for all); inhibits pH-induced amyloidogenesis of wild-type TTR and TTRV122I, indicating tetramer stabilization; stabilizes TTRV122I in serum isolated from patients with familial amyloid cardiomyopathy at 10 µM

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