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Medchemexpress LLC Acotiamide monohydrochloride trihydrate | 773092-05-0 | 99.79% | 1 ML
Supplier: Medchemexpress LLC HYB215510MM/1ML
Acotiamide monohydrochloride trihydrate is an orally active, selective, and reversible acetylcholinesterase (AChE) inhibitor with an IC50 of 1.79 μM. It enhances gastric contractility and accelerates delayed gastric emptying, making it a potential research compound for functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory conditions.
- Enhances gastric contractility and accelerates delayed gastric emptying.
- Reduces expression levels of IκB-α phosphorylation in stimulated macrophage cell lines.
- Significantly reduces TNF-α and IL-6 productions in stimulated NR8383 cells.
- Increases postprandial gastric motility index in a dose-dependent manner in vivo.
- Improves functional dyspepsia by inhibiting AChE.
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