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Cayman Chemical AcrBEcolI K12 10ug
Supplier: Cayman Chemical 2473310 UG
An aldose reductase inhibitor (IC50 0.026 M) inhibits AKR1B10 (IC50 33 M) decreases sorbitol and myo-inositol levels in the sciatic nerves of STZ-induced diabetic rats (2 mg/kg per day) decreases nerve fiber abnormalities and reverses slowing of MNCV in an STZ-induced diabetic rat model of peripheral neuropathy (2 mg/kg per day) decreases the pain threshold in STZ-induced diabetic mice overexpressing human aldose reductase (4 mg/kg per day) decreases metastasis in a KM20 human colorectal cancer mouse xenograft model (50 mg/kg per day)
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