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Medchemexpress LLC ACT-1004-1239 | 2178049-58-4 | 98.8% | C27H28F2N6O3 | 1 MG
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Supplier:  Medchemexpress LLC HY142617100MG

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ACT-1004-1239 is a potent, selective, orally active CXCR7 antagonist with an IC50 value of 3.2 nM. It is intended for research use only.

  • Inhibits human, dog, rat, mouse, guinea pig, macaque CXCR7 with IC50s of 3.2, 2.3, 3.1, 2.3, 0.6, 1.5 nM respectively.
  • Promotes oligodendrocyte precursor cell (OPC) differentiation by increasing CXCL12 levels.
  • Increases plasma CXCL12 concentration in naive male DBA/1 mice.
  • Reduces disease severity in MOG-induced experimental autoimmune encephalomyelitis (EAE) model.
  • Increases myelination in the Cuprizone-induced demyelination model mice.

Catalog No. 50-003-55636


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