ProSci Activin A Recombinant Protein

Catalog No.	Quantity
16-838-502	0.002 mg

Catalog No. 16-838-502 Supplier ProSci Supplier No. 402120002

Description

Recombinant Protein

Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, Follistatin. Human Activin A is a 26.0 kDa disulfide-linked homodimer of two β A chains, each containing 116 amino acid residues.

Specifications

• Accession Number: NP_001003652.1
• Gene ID (Entrez): 4087
• Quantity: 0.002 mg
• Source: (BTI-Tn-5B1-4) High-5 Insect cells
• Common Name: SMAD family member 2
• Gene Symbol: SMAD2
• Biological Activity: The ED50 was determined by its ability to inhibit the proliferation of murine MPC - 11 cells is ≤ 2 ng/mL, corresponding to a specific activity of ≥ 5 x 10⁵ units/mg.
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Sequence: GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
• Content And Storage: The lyophilized Activin A recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Activin A is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing Activin A recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein (at a cool and stable temperature.)
• Purity or Quality Grade: >95% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng / μg (1 EU/μg).
• Synonym: JV18, MADH2, MADR2, JV18-1, hMAD-2, hSMAD2, Mothers against decapentaplegic homolog 2, MAD homolog 2