Invitrogen™ Human ACVR1 [R206H], GST Tag Recombinant Protein

Catalog No.	Quantity
PV6232	10 μg

Catalog No. PV6232 Supplier Invitrogen™ Supplier No. PV6232

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Recombinant human ACVR1 (R206H) (147-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. Validated in LanthaScreen® Kinase Binding Assay Protocols available for simple use and optimized performance Multiple pack sizes available for convenient use Related Product:LanthaScreen® Eu Kinase Binding Assay Protein Form: Recombinant Assay Entry: Biochemical binding/kinetic.

ACVR1 (ALK2) belongs to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins which encodes activin A type I receptor. ACVR1 signals a particular transcriptional response in concert with activin type II receptors. Mutations in ACVR1 are associated with fibrodysplasia ossificans progressive (FOP) and the mutations are located in or adjacent to the GS regulatory region or active site of the kinase. The mutations in ACVR1 were predicted by protein structure homology modeling to activate the ACVR1 protein and enhance receptor signaling. Dysregulated ACVR1 kinase activity plays a role in the pathogenesis of FOP.

Specifications

• Concentration: See Label
• For Use With (Application): Kinase Assay
• Formulation: 50mM tris HCl with 25% glycerol, 150mM NaCl, 0.25mM DTT, 0.1mM PMSF, 0.1mM EDTA, 10mM glutathione and no preservative; pH 7.5
• Molecular Weight (g/mol): 67.6 kDa
• Name: Human ACVR1 [R206H], GST Tag
• pH Range: 7.5
• Purification Method: Purified
• Quantity: 10 μg
• Storage Requirements: -80°C, Avoid Freeze/Thaw Cycles
• Regulatory Status: RUO
• Common Name: ACVR1 (R206H Mutant)
• Protein Length: 147-end
• Product Type: Protein
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: GST-tag
• Sequence: 147-end
• Content And Storage: -80°C, Avoid Freeze/Thaw Cycles
• Assay Entry: Biochemical binding/kinetic
• Kinase Group: Serine/Threonine Kinase
• Target Entry: ACVR1 (ALK2) R206H
• Expression System: Insect cells
• Protein Form: Recombinant
• Form: Liquid