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Medchemexpress LLC Adapalene (CD271) | 106685-40-9 | 99.9% | C28H28O3 | 500 MG
Supplier: Medchemexpress LLC HYB0091500MG
Adapalene (CD271) is a third-generation synthetic retinoid primarily used for acne research. It functions as a potent RAR agonist and non-competitively inhibits GOT1 enzymatic activity, also demonstrating anti-tumor properties.
- Acts as a potent RAR agonist with varying AC50s for RAR subtypes.
- Inhibits viability of various cancer cell lines.
- Induces apoptosis and inhibits proliferation in ES-2 cells.
- Increases G1-phase population in LoVo or DLD1 cells.
- Inhibits GOT1 activity.
- Inhibits expression of plasma membrane-associated enzyme transglutaminase Type I.
- Inhibits growth of DLD1 cell-derived xenograft tumors in BALB/C nude mice, reducing tumor weight and volume.
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