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Medchemexpress LLC Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 99.8% | C10H16N5O8P | 5 G
Supplier: Medchemexpress LLC HYA0181A5G
Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist. It demonstrates significant antiviral activity against HSV-1 and HSV-2. In vitro studies show that its cell toxicity is negligible at concentrations of 25 to 400 μM in RAW264.7 cells.
- Negligible cell toxicity at 25 to 400 μM in RAW264.7 cells
- Attenuates mRNA expression of TNF-α and IL-6 in RAW264.7 cells
- Reduces NF-κB p65 recruitment to TNF-α, IL-6, and IL-1β gene promoters
- Increases hepatic adenosine levels and improves survival rates in mice
- Lowers serum AST and ALT levels, reduces liver necrosis and inflammatory cell infiltration
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