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AdipoGen AdipoRon HCl water soluble
Supplier: AdipoGen AGCR10156M010
Chemical. CAS 924416-43-3 free base. Formula C27H28N2O3 . HCl . H2O. MW 428.5 . 36.5 . 18.0. Orally-active adiponectin receptor AdipoR agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5-adenosine monophosphate-activated protein kinase AMPK in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha PGC1alpha which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice AdipoRs KO on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.
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