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Apexbio Technology LLC ADL5859 HCl 850173-95-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A29865.1
ADL5859 HCl (CAS 850173-95-4) is a potent selective agonist of the -opioid receptor exhibiting sub-nanomolar affinity and strong receptor selectivity In vitro studies have demonstrated that ADL5859 possesses robust -opioid agonist activity with minimal inhibition of the hERG channel In rat models of inflammatory mechanical allodynia oral administration of ADL5859 effectively reversed hypersensitivity with an ED50 of 1 4 mg/kg Its antiallodynic effects are antagonized by -opioid receptor antagonists confirming receptor specificity ADL5859 is under investigation as a candidate for the treatment of various pain conditions
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