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Cayman Chemical AdomeglIvnt 10mg
SDP

Supplier:  Cayman Chemical 2966810 MG

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An allosteric antagonist of the glucagon receptor; inhibits glucagon-induced increases in cAMP levels in HEK293 cells expressing the rat glucagon or GLP-1 receptors (IC50s = 1.8 and 1.2 µM, respectively) but has no effect on cAMP levels when used alone; inhibits increases in cAMP levels induced by GLP-1 or exendin-4 in HEK293 cells expressing the GLP-1 receptor (IC50s = 7 and 12 µM, respectively); decreases glucose-stimulated insulin secretion at 1 µM in combination with exendin (9-39) in isolated human islets but not glucose-stimulated glucagon secretion alone or in combination with exendin (9-39) in isolated mouse islets

Catalog No. 50-297-8748


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