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Cayman Chemical ADTL-EI1712 10mg
Supplier: Cayman Chemical 3060210 MG
A dual ERK1 and ERK5 inhibitor (IC50s = 40.43 and 64.5 nM, respectively); reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 µM; inhibits proliferation of HL-60 and MKN74 cancer cells (IC50s = 1.26 and 2.55 µM, respectively); reduces tumor growth and intratumor phosphorylation of ERK1/2 and ERK5 in an MKN74 mouse xenograft model at 50 mg/kg per day
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