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Apexbio Technology LLC AEBSF.HCl 30827-99-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A25735.1
AEBSF HCl is an irreversible serine protease inhibitor that covalently binds and inhibits several proteases including trypsin chymotrypsin plasmin and thrombin It has been applied in cellular research to study amyloid-beta (A ) production mechanisms In APP695 (K695sw)-transfected K293 cells AEBSF dose-dependently reduces A formation with an IC50 around 1 mM while in wild-type APP695-transfected HS695 and SKN695 cells it shows inhibitory effects with an IC50 of approximately 300 M Besides suppressing -cleavage AEBSF promotes -cleavage of APP In macrophage-mediated leukemic cell lysis assays incubation with AEBSF at 150 M for 6 hours achieves near-maximal protease inhibition thus impeding cell lysis
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