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Medchemexpress LLC Afimetoran (BMS-986256) | 2171019-55-7 | 99.4% | 444.57 | 50 MG
Supplier: Medchemexpress LLC HY13956750MG
Afimetoran (BMS-986256) is an orally active, selective, and highly bioavailable antagonist of Toll-like Receptor 7 and 8 (TLR7/8). It operates by inhibiting the activation of the NF-κB pathway, which is crucial in immune responses. Furthermore, Afimetoran can reverse TLR7-mediated resistance to steroid-induced apoptosis in plasma cell-like dendritic cells (pDCs). This compound is valuable for research into inflammation and autoimmune diseases, such as systemic lupus erythematosus.
- Orally active
- Selective TLR7/8 antagonist
- Highly bioavailable
- Inhibits NF-κB pathway
- Reverses steroid resistance
- Research applications
- Demonstrated in vivo efficacy
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