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Medchemexpress LLC AFM-30a (hydrochloride) | 99.7% | 502.97 | 10 MG
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Supplier:  Medchemexpress LLC HY125099A10MG

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AFM-30a hydrochloride is a potent and highly selective inhibitor of protein arginine deiminase 2 (PAD2). It binds to PAD2 with an EC50 value of 9.5 μM and inhibits H3 citrullination with an EC50 value of 0.4 μM. This compound is suitable for research into certain cancers and various autoimmune diseases, such as rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.

  • Potent protein arginine deiminase 2 (PAD2) inhibitor.
  • Demonstrates excellent PAD2-selectivity.
  • Binds to PAD2 with an EC50 value of 9.5 μM.
  • Inhibits H3 citrullination with an EC50 value of 0.4 μM.
  • Applicable for research on certain cancers and various autoimmune diseases, including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.
  • Exhibits low cytotoxicity in HEK293T/PAD2 cells.
  • Suppresses NLRP3 signaling and reduces airway remodeling in PAD2-/-transgenic mice.

Catalog No. 50-004-35718


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