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Medchemexpress LLC AFM-30a hydrochloride | 99.8% | 502.97 | 100 MG
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Supplier:  Medchemexpress LLC HY125099A100MG

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AFM-30a hydrochloride is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor. It binds to PAD2 with an EC50 value of 9.5 μM and inhibits H3 citrullination with an EC50 value of 0.4 μM. This compound is suitable for research into certain cancers and various autoimmune diseases, including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis.

  • Exhibits high potency and selectivity for PAD2.
  • Effectively inhibits H3 citrullination.
  • Has shown low cytotoxicity in HEK293T/PAD2 cells.
  • Can suppress NLRP3 signaling, decreasing airway remodeling in PAD2-/- transgenic mice.

Catalog No. 50-004-38555


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