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Medchemexpress LLC Afm-30a hydrochloride | 99.8% | 502.97 | 50 MG
SDP

Catalog No. 5000437091
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AFM-30a hydrochloride is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor with an EC50 value of 9.5 μM for PAD2. It also inhibits H3 citrullination with an EC50 value of 0.4 μM. This compound is intended for research related to certain cancers and various autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis. It exhibits low cytotoxicity in HEK293T/PAD2 cells and can suppress NLRP3 signaling and decrease airway remodeling in PAD2-/- transgenic mice.

  • Potent protein arginine deiminase 2 (PAD2) inhibitor.
  • Excellent PAD2-selectivity.
  • Inhibits H3 citrullination.
  • Can be used for research of certain cancers and autoimmune diseases (rheumatoid arthritis, multiple sclerosis, lupus, ulcerative colitis).
  • Low cytotoxicity in HEK293T/PAD2 cells.
  • Suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/- transgenic mice.

Catalog No. 50-004-37091 Supplier Medchemexpress LLC Supplier No. HY125099A50MG
May include imposed supplier surcharges.
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AFM-30a hydrochloride is a potent and selective protein arginine deiminase 2 (PAD2) inhibitor with an EC50 value of 9.5 μM for PAD2. It also inhibits H3 citrullination with an EC50 value of 0.4 μM. This compound is intended for research related to certain cancers and various autoimmune diseases such as rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis. It exhibits low cytotoxicity in HEK293T/PAD2 cells and can suppress NLRP3 signaling and decrease airway remodeling in PAD2-/- transgenic mice.

  • Potent protein arginine deiminase 2 (PAD2) inhibitor.
  • Excellent PAD2-selectivity.
  • Inhibits H3 citrullination.
  • Can be used for research of certain cancers and autoimmune diseases (rheumatoid arthritis, multiple sclerosis, lupus, ulcerative colitis).
  • Low cytotoxicity in HEK293T/PAD2 cells.
  • Suppresses NLRP3 signaling and decreases airway remodeling in PAD2-/- transgenic mice.

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