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Enzo Life Sciences AG-126 (25mg). CAS: 118409-62-4
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Supplier:  Enzo Life Sciences BMLEI2630025

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AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling. Alternative name: 3-Hydroxy-4-nitrobenzylidenemalononitrile. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml warm). Long Term Storage: Ambient.

Catalog No. 50-201-0645


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