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Apexbio Technology LLC AG-14361 328543-09-5 5mg
Supplier: Apexbio Technology LLC A41585
AG-14361 (CAS 328543-09-5) is a highly selective inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) exhibiting a Ki50 of less than 5 nM PARP-1 is integral to DNA repair and cell death pathways and is overexpressed in various tumor types AG-14361 has demonstrated the ability to sensitize homologous recombination (HR) and BRCA2-deficient cells to DNA-damaging agents at non-cytotoxic concentrations In human K562 cells AG-14361 enhances camptothecin-induced growth inhibition and cytotoxicity while increasing DNA single-strand breaks It also restores temozolomide sensitivity in mismatch repair-proficient cells Preclinical models indicate greater antitumor responses in BRCA2-deficient xenografts following AG-14361 administration supporting its use in DNA repair and cancer research
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